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E3 ligase Ligand 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
E3 ligase Ligand 1图片
CAS NO:1948273-03-7
规格:98%
分子量:481.05
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议
2g电议

产品介绍
E3ligaseLigand1是用于PROTAC技术中的E3连接酶配体,来自专利WO/2017/030814A1,化合物实例202。
CAS:1948273-03-7
分子式:C23H33ClN4O3S
分子量:481.05
纯度:98%
存储:Store at -20°C

Background:

E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.


E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand[1]. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition[2].



[1]. WO/2017/030814A1 [2]. Kanak R, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America (2016), 113(26), 7124-7129