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Ethyl 3-Aminobenzoate(methanesulfonate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ethyl 3-Aminobenzoate(methanesulfonate)图片
CAS NO:886-86-2
规格:98%
分子量:261.3
包装与价格:
包装价格(元)
25g电议
50g电议
100g电议

产品介绍
block the generation of action potentials through voltage-dependent Na+-channels
CAS:886-86-2
分子式:C9H11NO2 ? CH4O3S
分子量:261.3
纯度:98%
存储:Store at -20°C

Background:

Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.


Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. Sodium channels are also of special importance for the history of physiology.


In vitro: The major mode of action for ethyl 3-aminobenzoate was found to be nervous system suppression whereby the entrance of sodium into the nerve was inhibited, therefore limiting nerve membrane excitability. In addition, the nerve inhibition was facilitated by the lipid solubility of ethyl 3-aminobenzoate, which allowed it to move easily into the cell membrane to bind with sodium channels [1].


In vivo: Previous study evaluated the potency and dynamics of ethyl 3-aminobenzoate-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in Xenopus laevis tadpoles. Electrophysiological recordings of extraocular motor discharge and nerve activity were measured before, during and after administration of drugs. Results showed that ethyl 3-aminobenzoate and benzocaine, but not pancuronium could cause a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. Such results indicated that ethyl 3-aminobenzoate was able to block the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, suggesting that ethyl 3-aminobenzoate was effective as single-drug anesthetic for surgical interventions in anamniotes [2].


Clinical trial: So far, no clinical study has been conducted.


参考文献:
[1] K.  M. Carter, C. M. Woodley and R. S. Brown. A review of tricaine methanesulfonate for anesthesia of fish. Rev. Fish Biol. Fisheries 21, 51-59 (2011).
[2] C.  Ramlochansingh, F. Branoner, B. P. Chagnaud, et al. Efficacy of tricaine methanesulfonate (MS-222) as an anesthetic agent for blocking sensory-motor responses in Xenopus laevis tadpoles. PLoS One 9(7), e101606 (2014).