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Lacidipine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lacidipine图片
CAS NO:103890-78-4
规格:98%
分子量:455.54
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
L-type calcium channel blocker
CAS:103890-78-4
分子式:C26H33NO6
分子量:455.54
纯度:98%
存储:Store at -20°C

Background:

Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3].


参考文献:
[1]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9.
[2]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7.
[3]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.