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Milrinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Milrinone图片
CAS NO:78415-72-2
规格:98%
分子量:211.22
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
PDE-3 inhibitor
CAS:78415-72-2
分子式:C12H9N3O
分子量:211.22
纯度:98%
存储:Store at -20°C

Background:

Milrinone is a selective inhibitor of phosphodiesterase 3 (PDE-3) with a IC50 value of 56±12nM [1]


Milrinone has been noted to inhibit both members of the PDE3 family, PDE3A, which is prominent in heart, vascular smooth muscle, and platelets, as well as PDE3B, which is prominent in fat, liver, and pancreatic islets. Milrinone has shown the effect of concentration-dependent inhibition of PDE3 on the photolabelling with a IC50 value of 56±12nM. In addition, Milrinone has been reported to increase the accumulation of [3H]cAMP with a EC50 value of 5329±970nM in platelets. Apart from these, Milrinone has been revealed to have positive inotropic and vasodilatiry activities and thus used in clinical practice for short-trem treatment of patients who have the acute decompensated heart failure [1, 2].


参考文献:
[1] Tang KM1, Jang EK, Haslam RJ. Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 15;268(1):105-14.
[2] Cheung P1, Yang G, Boden G. Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. Metabolism. 2003 Nov;52(11):1496-500.