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BRD4770
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BRD4770图片
CAS NO:1374601-40-7
规格:98%
分子量:413.47
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
novel G9a(EHMT2) inhibitor
CAS:1374601-40-7
分子式:C25H23N3O3
分子量:413.47
纯度:98%
存储:Store at -20°C

Background:

BRD4770 is a novel G9a(EHMT2) inhibitor with EC50 of 5 uM (trimethylated H3K9 in PANC-1 cell).IC50 value: 5 uM (PANC-1 cell) [1]Target: G9a inhibitorBRD4770 activates the ATM pathway without inducing DNA damage, while the ATR pathway is not affected. BRD4770 is a novel probe for studying G9a and its role in cellular senescence.Treatment of 5 μM BRD4770 for 24 h decreased H3K9 trimethylation level by 23% in PANC-1 cells. BRD9539 also inhibits PRC2 activity.


参考文献:
[1]. Yuan Y, et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.