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Suramin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Suramin图片
CAS NO:145-63-1
包装:50mg
规格:98%
市场价:988元
分子量:1297.28

产品介绍
Suramin是具有各种生物活性的多磺化萘脲。Suramin是DNA topoisomerase II抑制剂,IC50值为5 μM。
CAS:145-63-1
分子式:C51H40N6O23S6
分子量:1297.28
纯度:98%
存储:Store at -20°C

Background:

Suramin is a polysulfonated naphthylurea with various biological activities. Suramin is a DNA topoisomerase II inhibitor with an IC50 of 5 μM. IC50: 5 μM (DNA topoisomerase II)[3]


Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 &#181M) than is DNA polymerase δ (IC50=36 &#181M), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 &#181M)[1]. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA-single-stranded DNA filaments[2]. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM[3].


Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen[4].


[1]. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7. [2]. Nautiyal A, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43. [3]. Bojanowski K, et al. Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcomacells. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3025-9. [4]. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073.