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PSI-7409 tetrasodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSI-7409 tetrasodium图片
CAS NO:1621884-22-7
规格:98%
分子量:592.12
包装与价格:
包装价格(元)
1mg电议
5mg电议
25mg电议

产品介绍
PSI-7409tetrasodium是一种sofosbuvir(PSI-7977)的5'-三磷酸活性代谢物,能够抑制HCVNS5Bpolymerases,对GT1b_Con1,GT2a_JFH1,GT3a和GT4aNS5B聚合酶的IC50值分别为1.6,2.8,0.7和2.6μM。
CAS:1621884-22-7
分子式:C10H16FN2Na4O14P3
分子量:592.12
纯度:98%
存储:Store at -20°C

Background:

PSI-7409 tetrasodium is an active 5’-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.


PSI-7409 tetrasodium is an active 5’-triphosphate metabolite, inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. PSI-7409 also weakly inhibits human DNA polymerase α, with an IC50 of 550 μM, but shows no inhibition on DNA Pol β and γ[1]. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μM over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h[2].



[1]. Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2’-deoxy-2’-fluoro-2’-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. [2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.