AZD9567(compound15)是一种有效的、选择性的、具有口服活性的,非甾体类糖皮质激素受体调节剂(SGRM),其IC50值为3.8nM。对SCW联合炎症表现出良好的疗效。
CAS:1893415-00-3
分子式:C27H28F2N4O3
分子量:494.53
纯度:98%
存储:Store at -20°C
Background:
AZD9567 (compound 15) is a potent, selective and oral active non-steroidal glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].
[1]. Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799.