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Glaucine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glaucine图片
CAS NO:475-81-0
规格:98%
分子量:355.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Glaucine is an alkaloid originally isolated from G.
CAS:475-81-0
分子式:C21H25NO4
分子量:355.4
纯度:98%
存储:Store at -20°C

Background:

Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties. It is structurally related to papaverine , a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes). It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation. Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling. This compound has been detected as a recreational drug capable of eliciting dissociative effects.