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CORM-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CORM-3图片
CAS NO:475473-26-8
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)294.61
FormulaC5H4ClNO5Ru
CAS No.475473-26-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 38 mg/mL (129 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESO=C1[O-][Ru+2]([Cl-])([C]=O)([C]=O)([C]=O)[NH2]C1
SynonymsCORM-3; CORM3; CORM 3
实验参考方法
In Vitro

In vitro activity: CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier.

In VivoCORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model.
Animal modelCBA mice transplanted with BALB/c hearts.
Formulation & DosageDissolved in saline; 40 mg/kg daily; i.p. injection
References

Circ Res. 2003 Jul 25;93(2):e2-8; Br J Pharmacol. 2005 Jul;145(6):800-10; Ann Rheum Dis. 2008 Sep;67(9):1211-7.