| In Vitro | In vitro activity: CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. |
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| In Vivo | CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. |
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| Animal model | CBA mice transplanted with BALB/c hearts. |
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| Formulation & Dosage | Dissolved in saline; 40 mg/kg daily; i.p. injection |
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| References | Circ Res. 2003 Jul 25;93(2):e2-8; Br J Pharmacol. 2005 Jul;145(6):800-10; Ann Rheum Dis. 2008 Sep;67(9):1211-7. |
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