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(±)-CPSI 1306
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-CPSI 1306图片
CAS NO:1309793-47-2
包装:10mg
规格:98%
市场价:3322元
分子量:310.3

产品介绍
macrophage inhibitory factor (MIF) inhibitor
CAS:1309793-47-2
分子式:C15H16F2N2O3
分子量:310.3
纯度:98%
存储:Store at -20°C

Background:

(±) -CPSI 1306 is an inhibitor of macrophage inhibitory factor (MIF) [1].


MIF is a proinflammatory cytokine and is an important regulation element of innate immunity. MIF plays an important role in the pathogenesis of many autoimmune inflammatory diseases [1].


In Skh-1 hairless mice with UVB exposure, CPSI 1306 reduced myeloperoxidase (MPO) activity and skin thickness and increased p53 expression and keratinocyte apoptosis. In mice with squamous carcinogenesis, CPSI-1306 slowed tumor growth and reduced p53 foci in non-tumor skin [1]. In ICR mice with streptozotocin (STZ) -induced non-insulin-dependent diabetes mellitus (NIDDM), CPSI 1306 significantly decreased blood glucose levels and reduced the levels of IL-6 and TNF-ɑ, the proinflammatory cytokines. These results suggested that MIF was involved in the pathogenesis of NIDDM [2]. In wild-type C57Bl/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG35–55), which induced experimental autoimmune encephalomyelitis (EAE), CPSI-1306 (1 mg/kg) reduced the inflammation and reduced the severity of disease [3].


参考文献:
[1].  Nagarajan P, Tober KL, Riggenbach JA, et al. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Mol Cancer Res, 2014, 12(9): 1292-1302.
[2].  Sanchez-Zamora Y, Terrazas LI, Vilches-Flores A, et al. Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J, 2010, 24(7): 2583-2590.
[3].  Kithcart AP, Cox GM, Sielecki T, et al. A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease. FASEB J, 2010, 24(11): 4459-4466.