您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > HZ-1157
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
HZ-1157
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HZ-1157图片
CAS NO:1009734-33-1
规格:98%
分子量:232.28
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
HCV NS3/4A protease inhibitor
CAS:1009734-33-1
分子式:C12H16N4O
分子量:232.28
纯度:98%
存储:Store at -20°C

Background:

HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 μmol/L [1].


The NS3 protease of HCV is a prime target for the development of anti-HCV agents because it cleaves the viral polyprotein and liberates NS3, NS4A, NS4B, NS5A, and NS5B, allowing them to function normally in viral RNA replication, and it deactivates many host proteins involved in innate immunity to foster a favorable cellular environment for HCV replication. The NS3 protease is most active when complexed with its cofactor NS4A [1].


In vitro: Huh7.5.1 cell line stably transfected with HCV NS3/4A protease reporter was established to investigate the anti-HCV mechanism of HZ-1157 (0.001