Selective eIF2α inhibitor
CAS:405060-95-9
分子式:C21H17Cl3N4OS
分子量:479.81
纯度:98%
存储:Store at -20°C
Background:
IC50: A cell-permeable and selective inhibitor of eIF2α dephosphorylation with an IC50 of 15 M.
The eukaryotic translation initiation factor 2 subunit α (eIF2α) is crucial in protein synthesis. eIF2α phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2α. [1]
In vitro: This agent is reported to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50