Background:

L-carnitine (Levocarnitine) is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.Target: OthersL-carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-carnitine (Levocarnitine) can also be found in many foods, but red meats, such as beef and lamb, are the best choices for adding carnitine into the diet [1]. Administering L-carnitine (510 mg/day) to patients with the disease. L-carnitine (Levocarnitine) treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine (Levocarnitine) efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration [2]. L-carnitine (Levocarnitine) and its derivatives show promise in the treatment of chronic conditions and diseases associated with mitochondrial dysfunction but further translational studies are needed to fully explore their potential [3].

参考文献:
[1]. Marcovina, S.M., et al., Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine. Transl Res, 2013. 161(2): p. 73-84.
[2]. Pekala, J., et al., L-carnitine--metabolic functions and meaning in humans life. Curr Drug Metab, 2011. 12(7): p. 667-78.
[3]. Miyagawa, T., et al., Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One, 2013. 8(1): p. e53707.