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Fructose 2,6-biphosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fructose 2,6-biphosphate图片
CAS NO:79082-92-1
规格:98%
分子量:340.12
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Fructose 2,6-bisphosphate 是 6-磷酸果糖-1-激酶 (PFK-1) 的有效刺激剂,也是果糖-1,6-二磷酸酶的抑制剂。
CAS:79082-92-1
分子式:C6H14O12P2
分子量:340.12
纯度:98%
存储:Store at -20°C

Background:

Fructose 2,6-bisphosphate is a potent stimulator of 6-Phosphofructo-1-kinase (PFK-1) and also inhibits Fructose-1,6-Bisphosphatase. PFK-1, Fructose-1,6-Bisphosphatase[1]


A concentration-dependent inhibition of fructose-1,6-Bisphosphatase by Fructose 2,6-bisphosphate is observed. Another characteristic of this inhibition is that it changes the saturation curve from hyperbolic to sigmoidal. This effect is clearly apparent at 25 pM Fructose 2,6-bisphosphate. It appears that the inhibitory actions of Fructose 2,6-bisphosphate and of AMP are synergistic. Indeed, at 10 pM fructose 1,6-bisphosphate, the addition of AMP alone causes a 35% inhibition but, it increases the inhibition by 1 pM Fructose 2,6-bisphosphate from 20% to 80%[1].



[1]. Van Schaftingen E, et al. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proc Natl Acad Sci U S A. 1981 May;78(5):2861-3.