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Alosetron(Hydrochloride(1:X))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alosetron(Hydrochloride(1:X))图片
CAS NO:132414-02-9
规格:98%
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Alosetron Hydrochloride(1:X) (GR 68755 Hydrochloride(1:X)) 是5-HT3受体拮抗剂,可作用于肠易激综合征。
CAS:132414-02-9
分子式:C17H18N4O.xHCl
分子量:
纯度:98%
存储:Store at -20°C

Background:

Alosetron Hydrochloride(1:X) (GR 68755 Hydrochloride(1:X)) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: N/ATarget: 5-HT3 ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron’s 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia.




[1]. Cremonini F, Nicandro JP, Atkinson V, Shringarpure R, Chuang E, Lembo A.Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.Aliment Pharmacol Ther. 2012 Sep;36(5):437-48. doi: 10.1111/j.1365-2036.2012.05208.x. [2]. Nicandro JP, Shin P, Chuang E.Evaluation of treatment continuation with alosetron by IBS-D severity criteria.Curr Med Res Opin. 2012 Mar;28(3):449-56. [3]. Bleser S.Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving patient outcomes.Curr Med Res Opin. 2011 Mar;27(3):503-12. [4]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74 [5]. Alosetron: an effective treatment for diarrhea-predominant irritable bowel syndrome By Harris, Lucinda A.; Chang, Lin From Women’s Health (2007), 3(1), 15-27