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(R)-(-)-Rolipram
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(R)-(-)-Rolipram图片
CAS NO:85416-75-7
规格:98%
分子量:275.34
包装与价格:
包装价格(元)
100mg电议
200mg电议
10mg电议
50mg电议

产品介绍
(R)-(-)-Rolipram是cAMP-特异的PDE4抑制剂,IC50为220nM。在抑制PDE4膜结合实验中其抑制性高于(+)-rolipram 2.5倍。
CAS:85416-75-7
分子式:C16H21NO3
分子量:275.34
纯度:98%
存储:Store at -20°C

Background:

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.


The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].



[1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.