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Nitromifene(CI628)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nitromifene(CI628)图片
CAS NO:10448-84-7
规格:98%
分子量:444.52
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Nitromifene是一个雌激素受体(ER)拮抗剂。
CAS:10448-84-7
分子式:C27H28N2O4
分子量:444.52
纯度:98%
存储:Store at -20°C

Background:

Nitromifene is an antagonist of estrogen receptor (ER).


Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].



[1]. Ruenitz PC, et al. Characterization of MCF 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites. J Steroid Biochem. 1989 Sep;33(3):365-9.