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Becatecarin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Becatecarin图片
CAS NO:119673-08-4
规格:98%
分子量:669.6
包装与价格:
包装价格(元)
250ug电议
1mg电议

产品介绍
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.
CAS:119673-08-4
分子式:C33H34Cl2N4O7
分子量:669.6
纯度:98%
存储:Store at -20°C

Background:

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.