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Deltorphin I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Deltorphin I图片
CAS NO:122752-15-2
包装:1mg
规格:98%
市场价:905元
分子量:768.87

产品介绍
δ-opioid receptor agonist
CAS:122752-15-2
分子式:C37H52N8O10
分子量:768.87
纯度:98%
存储:Store at -20°C

Background:

Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.


Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05,<0.05 and<0.05), and this effect is dose dependent[1].


参考文献:
[1]. Dai X, et al. Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice. Behav Brain Res. 2007 Aug 22;182(1):21-7.