CAS NO: | 122752-15-2 |
包装: | 1mg |
规格: | 98% |
市场价: | 905元 |
分子量: | 768.87 |
Background:
Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05,<0.05 and<0.05), and this effect is dose dependent[1].
参考文献:
[1]. Dai X, et al. Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice. Behav Brain Res. 2007 Aug 22;182(1):21-7.