Background:

Estrone is an estrogenic hormone.Target: Estrogen Receptor/ERREstrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women [1, 2].

参考文献:
[1]. Hoffmann, B., et al., [Profiles of estrone, estrone sulfate and progesterone in donkey (Equus asinus) mares during pregnancy]. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2014. 42(1): p. 32-9.
[2]. Oneson, I.B. and S.L. Cohen, The nature of the conjugated estrone in human pregnancy urine. Endocrinology, 1952. 51(3): p. 173-82.