OICR-0547是与OICR-9429密切相关的衍生产品。OICR-9429是Wdr5-MLL相互作用的新型小分子拮抗剂,而OICR-0547不能与WDR5结合。
CAS:1801873-49-3
分子式:C28H29F3N4O4
分子量:542.55
纯度:98%
存储:Store at -20°C
Background:
OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction, while OICR-0547 cannot bind to WDR5.
[1]. Grebien F, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-578.