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(±)12-HEPE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)12-HEPE图片
CAS NO:81187-21-5
规格:98%
分子量:318.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议
250ug电议

产品介绍
(±)12-HEPE is produced by non-enzymatic oxidation of EPA.
CAS:81187-21-5
分子式:C20H30O3
分子量:318.5
纯度:98%
存储:Store at -20°C

Background:

(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 µM, respectively. These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8.8 µM).