Valacyclovir (Zelitrex; BW256; Val-ACV; Valtrex; BW-256U87) is a potent antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Valacyclovir is a prodrug that has to be converted in vivo to aciclovir. As an esterified prodrug of aciclovir, Valacyclovir has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase.

纯度：≥98%

CAS：124832-26-4