Psoromic acid is an inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 uM) and P.
CAS：7299-11-8
分子式：C18H14O8
分子量：358.3
纯度：98%
存储：Store at -20°C

Background:

Psoromic acid is an inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 uM) and P. falciparum fatty acid synthesis (FAS) II. It shows cytotoxic effects on primary rat cerebral cortex and human cancer U87MG cell lines in vitro (IC50s = 79.40 and 56.22 mg/L, respectively). It also is cytotoxic against human KB cancer cells (IC50 = 31.6 uM). It shows moderate activity against liver stage P. beghei (IC50 = 31.6 uM) and drug-resistant blood stage P. falciparum (IC50 = 29.2 uM). The maximum tolerated dose in zebrafish larvae is 15.5 uM.