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Calcium Ionophore I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calcium Ionophore I图片
CAS NO:58801-34-6
规格:98%
分子量:684.99
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Ca2+-selective ionophore
CAS:58801-34-6
分子式:C38H72N2O8
分子量:684.99
纯度:98%
存储:Store at -20°C

Background:

Calcium Ionophore I, also known as CA 1001 or ETH 1001, is a Ca2+-selective ionophore [1][2].


Ionophores can selectively change the ionic permeability of a membrane and therefore can be used to mimic the properties of the ion carriers normally found in biological membranes and to study membrane function [2].


Calcium Ionophore I is a Ca2+-selective neutral carrier. In Ca2+ loaded IOVs derived from human RBCs, ETH 1001 promoted Ca2+ flux across RBC membranes. The amount of Ca2+ in cells treated with ETH 1001 was significantly higher than in control cells. In the presence of external Ca2+, ETH 1001 was capable of transporting Ca2+ into RBCs [3]. CA 1001 was also used to construction of the Ca2+-selective membrane microelectrode [4][5].


参考文献:
[1]Dagostino M, Lee CO.? Neutral carrier Na+- and Ca2+-selective microelectrodes for intracellular application. Biophys J. 1982 Dec;40(3):199-207.
[2]Caroni P, Gazzotti P, Vuilleumier P, et al.? Ca2+ transport mediated by a synthetic neutral Ca2+ -ionophore in biological membranes. Biochim Biophys Acta. 1977 Nov 1;470(3):437-45.
[3]Hinds TR, Vincenzi FF.? The effect of ETH 1001 on ion fluxes across red blood cell membranes. Cell Calcium. 1985 Jun;6(3):265-79.
[4]Lücke A, Lehmenkühler A, Speckmann EJ.? The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42.
[5]Lee MH, Yoo CL, Lee JS, et al.? Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7.