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10-Nitrolinoleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
10-Nitrolinoleate图片
CAS NO:774603-04-2
规格:98%
分子量:325.4
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议

产品介绍
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species.
CAS:774603-04-2
分子式:C18H31NO4
分子量:325.4
纯度:98%
存储:Store at -20°C

Background:

10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxisome proliferator-activated receptor γ (PPARγ; Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake. Nitrolinoleates can also be metabolized by smooth muscle cells to produce nitrite derivatives which in turn form NO, leading to increased cGMP production and smooth muscle relaxation. Through the same mechanism, nitrolinoleate-derived NO suppresses leukocyte adhesion, in part through nitrosation of CD40. Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions.