Background:

GBLD 345 is a potent agonist of benzodiazepine receptor.

Benzodiazepine receptor is an allosteric modulatory site on GABAA receptor [1]. The GABAA receptor is a ligand-gated ion channel and activated by γ-aminobutyric acid (GABA). The GABAA receptor selectively permits Cl- through its pore and results in hyperpolarization of the neuron, which causes an inhibitory effect on neurotransmission.

GBLD 345 is a potent benzodiazepine receptor agonist with IC50 value of 1 nM against diazepam.

Reference:
[1].  Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci, 1994, 19(1): 24-29.