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UCL 2077
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UCL 2077图片
CAS NO:918311-87-2
规格:98%
分子量:350.46
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Slow afterhyperpolarization (sAHP) channel blocker,KCNQ1 and KCNQ2 inhibitor
CAS:918311-87-2
分子式:C25H22N2
分子量:350.46
纯度:98%
存储:Store at -20°C

Background:

UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2].


参考文献:
[1]. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.
[2]. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.