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DMP 543
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DMP 543图片
CAS NO:160588-45-4
规格:98%
分子量:412.44
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
K+ channel blocker and acetylcholine release stimulator
CAS:160588-45-4
分子式:C26H18F2N2O
分子量:412.44
纯度:98%
存储:Store at -20°C

Background:

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].


DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].


参考文献:
[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409.
[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.