selective, reversible inhibitor of fatty acid synthase(FAS)
CAS：13616-29-0
分子式：C23H22N8O5S2
分子量：554.6
纯度：98%
存储：Store at -20°C

Background:

GSK837149A is a selective and reversible inhibitor of fatty acid synthase (FAS) [1].

Fatty acids are essential for all the living cells and have a diversity of biological functions. Fatty acids are fundamental aliphatic acids served as energy production and storage, cellular structure and as intermediates in the biosynthesis of hormones and other biologically important molecules. In cells, fatty acids provide structural integrity to cellular membranes and cell walls. Fatty acids have been also involved in the transmission of cellular signals and can be used to modify proteins during post-translational processing. Fatty acid synthase has been involved in catalyzing the formation of long-chain fatty acids from acetyl-CoA and malonyl-CoA in the presence of NADPH [1].

GSK837149A inhibited FAS in a reversible manner, with a Ki value of