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4'-hydroxy Chalcone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4'-hydroxy Chalcone图片
CAS NO:2657-25-2
规格:98%
分子量:224.3
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议
50g电议

产品介绍
4'-hydroxy Chalcone is a chalcone metabolite with diverse biological activities.
CAS:2657-25-2
分子式:C15H12O2
分子量:224.3
纯度:98%
存储:Store at -20°C

Background:

4’-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4’-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4’-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.