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YC 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YC 1图片
CAS NO:170632-47-0
规格:98%
分子量:304.34
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
soluble guanylyl cyclase (sGC) activator
CAS:170632-47-0
分子式:C19H16N2O2
分子量:304.34
纯度:98%
存储:Store at -20°C

Background:

IC50: 1.2 M for hypoxia-induced HIF-1 transcriptional activity


YC-1 is a novel anticancer drug initially developed as an inhibitor of HIF-1α. Hypoxia-inducible factor-1α (HIF-1α) is a basic helix-loop-helix transcription factor regulating expression of VEGF and other genes which modulate survival, growth and metastasis of tumor cells under conditions of hypoxia.


In vitro: YC-1 could inhibit platelet aggregation and vascular contraction via activating soluble guanylyl cyclase and was originally developed as a potential therapeutic agent for circulation disorders. YC-1 completely inhibited HIF-1α expression at the post-transcriptional level and consequently blocked the transcription factor activity of HIF-1 in hepatoma cells under hypoxic conditions, indicating that such effects of YC-1 were likely to be associated with the oxygen-sensing pathway but not with the soluble guanylyl cyclase activation [1].


In vivo: Compared with tumors from vehicle-treated mice, tumors from YC-1-treated group were found to be statistically smaller and less vascularized. In addition, tumors from YC-1-treated group expressed lower levels of HIF-1α as well as HIF-1-inducible genes, regardless of tumor type [1].


Clinical trial: N/A


Reference:
[1] Yeo EJ,Chun YS,Cho YS,Kim J,Lee JC,Kim MS,Park JW.  YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst.2003 Apr 2;95(7):516-25.