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Dafadine-A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dafadine-A图片
CAS NO:1065506-69-5
规格:98%
分子量:391.46
包装与价格:
包装价格(元)
100mg电议
200mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Dafadine-A是dafadine类似物,是C. elegans DAF-9 细胞色素P450抑制剂,还能抑制哺乳动物的CYP27A1。
CAS:1065506-69-5
分子式:C23H25N3O3
分子量:391.46
纯度:98%
存储:Store at -20°C

Background:

Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.




[1]. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3.