AZD4407是一种有效的5-脂氧合酶(5-lipoxygenase)抑制剂。
CAS：166882-70-8
分子式：C19H21NO3S2
分子量：375.5
纯度：98%
存储：Store at -20°C

Background:

AZD 4407 is a potent 5-lipoxygenase inhibitor.

In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407)[1].

[1]. Jonathan Hutton, et al. Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407. Org Process Res Dev. 1997 Jan 15;1(1): 61-67.