Choleratoxin是由霍乱弧菌产生的多功能蛋白质。Choleratoxin不仅仅是引起霍乱的另一种肠毒素，而且还能以多种方式影响免疫系统。
CAS：9012-63-9
分子量：
纯度：98%
存储：Store at -20°C

Background:

Cholera toxin is produced by V. cholerae and is a multimeric enterotoxin that consists of a single A subunit surrounded by five B subunits.[1] Following binding to the membrane of enteric cells, the toxin is endocytosed and travels to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase, locking it in an ‘on’ position.[2] The increased intracellular concentration of cAMP causes hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and severe diarrhea characteristic of the disease cholera.[1]

Reference:
[1]. Cho, J.A., Chinnapen, D.J.F., Amar, E., et al. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front. Cell. Infect. Microbiol. 2(51), (2012).
[2]. van Heyningen, S., and King, C.A. Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes. Biochem J. 146(1), 269-271 (1975).