Metanicotine, formerly known as RJR-2403 and TC-2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 +/- 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 +/- 155 nM and Emax = 91 +/- 8% for RJR-2403; EC50 = 591 +/- 120 nM and Emax = 100 +/- 25% for nicotine) . Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats. RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801. References: Fedotova YO. [Co-administration of RJR-2403 with low dose of 17beta-estradiol on spatial learning in ovariectomized rats]. Patol Fiziol Eksp Ter. 2013 Jul-Sep;(3):37-41. Russian. PubMed PMID: 24340617.

纯度：≥98%

CAS：220662-95-3