| CAS NO: | 2055397-28-7 |
| 规格: | 98% |
| 分子量: | 389.38 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
Background:
Target: lysine acetyltransferases, KAT6A(MOZ), KAT6B(MORF/QKF)
WM-1119 induces cell cycle exit and cellular senescence without causing DNA damage. Senescence is INK4A/ARF-dependent and is accompanied by changes in gene expression that are typical of loss of KAT6A function. WM-1119, which has increased bioavailability, arrests the progression of lymphoma in mice
Data:
Treatment with WM-1119 arrests lymphoma growth.
Growth inhibition assays of Eμ-Myc lymphoma cell line EMRK1184 treated with WM-1119 and WM-8014 at the doses indicated.
KD(KAT6A)=0.002μM KD(KAT5) = 2.2μM KD(KAT7) = 0.5 μM
参考文献
1. Baell JB, et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 2018 Aug;560(7717):253-257.
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