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BH3I-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BH3I-1图片
CAS NO:300817-68-9
规格:98%
分子量:400.31
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Bcl-2 or Bcl-XL inhibitor
CAS:300817-68-9
分子式:C15H14BrNO3S2
分子量:400.31
纯度:98%
存储:Store at -20°C

Background:

IC50: 293.95 μM


BH3I-1 is an inhibitor of Bcl-2 or Bcl-XL.


It has been reported that a disregulation of the Bcl-2/ Bcl-XL family proteins may result in the development of cancer, since the failure of the inactivation of pro-apoptotic pathways, or the activation of anti-apoptotic pathways, may occur in the regulation processes.


In vitro: The Bcl-2 inhibitors BH3I-1 and it analog BH3I-2 had been applied as lead compounds to find possible Bcl-2 or Bcl-X(L) inhibitors by using computer-assisted screening of in-house database. The identified compounds were further studied regarding their possible application as a drug. It was found that the induction of apoptosis, which was shown as number of hypodiploid cells, was increased by adding BH3I-1 and it analog BH3I-2 to Bjab Bcl-XL and Bjab neo/mock cells. In addition, the effects of the pro-apoptotic proteins Bax and Bak on the induction of apoptosis via BH3I-1 and it analog BH3I-2 were investigated with a variety of knockout cell lines, and resulted showed that the presence or absence of Bak or Bax has no significant influence on the amount of apoptotic events induced by BH3I-1 and it analog BH3I-2 [1].


In vivo: Currently, there is no animial in vivo data reported.


Clinical trial: Up to now, BH3I-1 is still in the preclinical development stage.


Reference:
[1] Füllbeck M,Gebhardt N,Hossbach J,Daniel PT,Preissner R.  Computer-assisted identification of small-molecule Bcl-2 modulators. Comput Biol Chem.2009 Dec;33(6):451-6.