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Balsalazide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Balsalazide图片
CAS NO:80573-04-2
规格:98%
分子量:357.32
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍

anti-inflammatory drug
CAS:80573-04-2
分子式:C17H15N3O6
分子量:357.32
纯度:98%
存储:Store at -20°C

Background:

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

参考文献:
[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.
[2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.