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HA 130
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HA 130图片
CAS NO:1229652-21-4
规格:98%
分子量:463.29
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
autotaxin inhibitor
CAS:1229652-21-4
分子式:C24H19BFNO5S
分子量:463.29
纯度:98%
存储:Store at -20°C

Background:

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.


HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].


HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].


参考文献:
[1]. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924.
[2]. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048.