Dihydrexidine (DAR-100) 是一种高效、选择性和全效的 D1 多巴胺受体激动剂，IC50 值为 10 nM，对 D2 受体有一定的亲和力。Dihydrexidine (DAR-100) 具有高效的抗帕金森活性。
CAS：123039-93-0
分子式：C17H17NO2
分子量：267.32
纯度：98%
存储：Store at -20°C

Background:

Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3]. IC50: 10 nM (D1 dopamine receptor)[1]

[1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. [2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42.