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MS21570
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MS21570图片
CAS NO:65373-29-7
规格:98%
分子量:237.34
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
MS21570是GPR171的选择性拮抗剂,其IC50值为220nM.
CAS:65373-29-7
分子式:C10H11N3S2
分子量:237.34
纯度:98%
存储:Store at -20°C

Background:

MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM.



MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist[1].


[1]. Bobeck EN, et al. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.