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α-(difluoromethyl)-DL-Arginine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-(difluoromethyl)-DL-Arginine图片
CAS NO:69955-43-7
规格:98%
分子量:224.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Bacteria synthesize the cellular growth factor putrescine through a number of pathways.
CAS:69955-43-7
分子式:C7H14F2N4O2
分子量:224.2
纯度:98%
存储:Store at -20°C

Background:

Bacteria synthesize the cellular growth factor putrescine through a number of pathways. One pathway involves the decarboxylation of arginine by arginine decarboxylase to produce agmatine, which is then degraded to putrescine. While important for various cellular processes (e.g., cell division, differentiation, environmental stress responses) in all living organisms, including plants, high levels of this polyamine can be toxic. α-(difluoromethyl)-DL-Arginine (DFMA) is an enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 µM), P. aeruginosa, and K. pneumoniae. At 0.01 mM, it has been shown to prevent the osmotic stress-induced increase in arginine decarboxylase activity and putrescine synthesis in oat leaf cells. DFMA can also reduce the growth of T. cruzi in mammalian host cells at a minimal concentration of 10 mM and prevent the growth of C. parvum in a T cell receptor alpha-deficient mouse model when combined with various polyamine analogs.