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POV-PC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
POV-PC图片
CAS NO:121324-31-0
规格:98%
分子量:593.7
包装与价格:
包装价格(元)
25mg电议
1mg电议
5mg电议
10mg电议

产品介绍
Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.
CAS:121324-31-0
分子式:C29H56NO9P
分子量:593.7
纯度:98%
存储:Store at -20°C

Background:

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC confers CD36 scavenger receptor binding affinity more potently than any hydroperoxy PC species, and may be one of the more important structural determinants of oxLDL. Treatment of cultured endothelial cells with POV-PC stimulates monocyte binding, stimulates intracellular cAMP production, and strongly inhibits the LPS-induced binding of neutrophils.