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Inogatran(H-314-27)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Inogatran(H-314-27)图片
CAS NO:155415-08-0
规格:98%
分子量:438.56
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Inogatran是一种合成的thrombin抑制剂,主要用于预防动脉和静脉血栓性疾病。
CAS:155415-08-0
分子式:C21H38N6O4
分子量:438.56
纯度:98%
存储:Store at -20°C

Background:

Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.



Inogatran (0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis[1]. Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model[2].


[1]. Ignasiak DP, et al. Effects of Intravenous Enoxaparin and Intravenous Inogatran in an Electrolytic Injury Model of Venous Thrombosis in the Dog. J Thromb Thrombolysis. 1998 Nov;6(3):199-206. [2]. Chi L, et al. Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J Thromb Thrombolysis. 2001 Feb;11(1):19-31.