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Dixyrazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dixyrazine图片
CAS NO:2470-73-7
规格:98%
分子量:427.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Dixyrazine是Phenothiazine衍生物,可预防注射硫酸鱼精蛋白引起的脑水肿。
CAS:2470-73-7
分子式:C24H33N3O2S
分子量:427.6
纯度:98%
存储:Store at -20°C

Background:

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.



Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF)[1]. The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats[2].


[1]. Westergren I, et al. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Acta Neurochir (Wien). 1991;113(3-4):171-5. [2]. Johansson BB, et al. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Stroke. 1982 Mar-Apr;13(2):220-5.