BL-1249 is a novel, potent and selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channel activator. BL-1249 potently activates K2P2.1(TREK-1) and K2P10.1(TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. Extracellular application of BL-1249 activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM).

纯度：≥98%

CAS：18200-13-0