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AM 114
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AM 114图片
CAS NO:856849-35-9
规格:98%
分子量:377.01
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
20S proteasome inhibitor
CAS:856849-35-9
分子式:C20H21B2NO5
分子量:377.01
纯度:98%
存储:Store at -20°C

Background:

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50of approximately 1 μM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins. AM 114 also exerts anti-cancer activity against cancer cells, which potently inhibits the growth of human colon cancer HCT116 cells with values of IC50of 1.5 μM and 0.6 μM in MTT and colony formation assays respectively.


Reference


[1].Achanta G, Modzelewska A, Feng L, Khan SR, Huang P. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol Pharmacol. 2006 Jul;70(1):426-33. Epub 2006 Apr 24.