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KRIBB11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KRIBB11图片
CAS NO:342639-96-7
规格:98%
分子量:284.27
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM.
CAS:342639-96-7
分子式:C13H12N6O2
分子量:284.27
纯度:98%
存储:Store at -20°C

Background:

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM.


KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 uM, and an IC50 of 20-30 uM[2].


KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss[1].


参考文献:
[1]. Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286(3):1737-47.
[2]. Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.